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Title: Daily consumption of milk enriched with fish oil, oleic acid, minerals and vitamins reduces cell adhesion molecules in healthy children
Authors: Romeo, J., Wärnberg, J., García-Mármol, E., Rodríguez-Rodríguez, M., Díaz, L. E., Gómez Martínez, Sonia, Cueto, B., López-Huertas, E., Cepero, M., Boza, J. J., Fonollá, J., Marcos, Ascensión
Issue Date: 2011
Publisher: Elsevier
Abstract: Background and aims: Several studies have suggested that polyunsaturated fatty acids, vitamins and minerals have beneficial effects on lipid profile and systemic inflammation in adults. Methods and results: We examined the effects of a daily intake of milk enriched with long-chain polyunsaturated fatty acids, oleic acid, carbohydrates, vitamins, minerals and low in saturated fatty acids (SFAs) for 5 months, on several cardiovascular (CVD) risk biomarkers in healthy children aged 8-14 years. In a randomized double-blind placebo-controlled trial, a total of 107 children of both genders were assigned to two study groups: 1) a supplemented group (SG, n=53) who consumed 0.6. L/day of an enriched dairy product, and 2) a control group (CG, n=54) who consumed 0.6. L/day of standard whole milk. Both groups consumed the dairy drinks for 5 months, in addition to their usual diet. Serum levels of adhesion molecules as indices of vascular endothelial cell activation were assessed in both groups at 0 and 5 months as well as white blood cell counts, lipid profile, serum proteins, total serum calcium, 25-OH vitamin D, glucose, insulin and adiponectin. In the enriched dairy drink supplemented group, adhesion molecules E-selectin and ICAM-1 as well as lymphocyte levels decreased while plasma docosahexaenoic acid (DHA) and serum calcium concentrations increased. In the control group, serum total protein, transferrin, total cholesterol, HDL-cholesterol and adiponectin concentrations decreased. Conclusion: The consumption of a milk enriched with fish oil, oleic acid, minerals and vitamins reduced indices of endothelial cell activation in the studied group of healthy children. © 2009 Elsevier B.V.
Identifiers: doi: 10.1016/j.numecd.2009.08.007
issn: 0939-4753
Citation: Nutrition, Metabolism and Cardiovascular Diseases 21: 113- 120 (2011)
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