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http://hdl.handle.net/10261/61742
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dc.contributor.author | Garrido, Pilar | - |
dc.contributor.author | Bárcena, Paloma | - |
dc.contributor.author | Balanzategui, Ana | - |
dc.contributor.author | González, Marcos | - |
dc.contributor.author | García-Montero, Andrés | - |
dc.contributor.author | Almeida, Julia | - |
dc.contributor.author | Orfao, Alberto | - |
dc.date.accessioned | 2012-12-03T11:56:37Z | - |
dc.date.available | 2012-12-03T11:56:37Z | - |
dc.date.issued | 2007 | - |
dc.identifier | doi: 10.1182/blood-2006-05-022277 | - |
dc.identifier | issn: 0006-4971 | - |
dc.identifier | e-issn: 1528-0020 | - |
dc.identifier.citation | Blood 109(11): 4890-4898 (2007) | - |
dc.identifier.uri | http://hdl.handle.net/10261/61742 | - |
dc.description.abstract | Monoclonal TCRαβ+/CD4+ T-large granular lymphocyte (T-LGL) lymphocytosis is a T-cell disorder with a restricted TCR-Vβ repertoire. In the present study we explored the potential association between the expanded TCR-Vβ families, the CDR3 sequences of the TCR-Vβ gene, and the HLA genotype of patients with monoclonal TCRαβ+/CD4+ T-LGL lymphocytosis. For that purpose, 36 patients with monoclonal TCRαβ+/CD4 + T-LGL lymphocytosis (15 TCR-Vβ13.1 versus 21 non-TCR-Vβ13.1) were selected. For each patient, both the HLA (class I and II) genotype and the DNA sequences of the VDJ-rearranged TCR-Vβ were analyzed. Our results show a clear association between the TCR-Vβ repertoire and the HLA genotype, all TCR-Vβ13.1+ cases being HLADRB1* 0701 (P = .004). Interestingly, the HLA-DR7/TCR-Vβ13.1- restricted T-cell expansions displayed a highly homogeneous and strikingly similar TCR arising from the use of common TCR-Vβ gene segments, which shared (1) unique CDR3 structural features with a constantly short length, (2) similar combinatorial gene rearrangements with frequent usage of the Jβ1.1 gene, and (3) a homolog consensus protein sequence at recombination junctions. Overall, these findings strongly support the existence of a common antigendriven origin for monoclonal CD4+ T-LGL lymphocytosis, with the identification of the exact peptides presented to the expanded T cells deserving further inves tigations. | - |
dc.description.sponsorship | This work has been partially supported by the following grants: FIS 02/1244 and FIS 05/0399, from the Ministerio de Sanidad y Consumo, Madrid, Spain; RETICC RD06/0020/0035 from the Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Madrid, Spain; SA 103/03, from the Consejería de Educación y Cultura, Junta de Castillo y León, Valladolid, Spain; and 05/287, from the Consejería de Salud, Junta de Andalucía, Sevilla, Spain. P.B. is supported by a grant from the University of Salamanca (Reg. N. 430). A.C.G.-M. is supported by a grant from FIS (CP03/00035). | - |
dc.language.iso | eng | - |
dc.publisher | American Society of Hematology | - |
dc.rights | closedAccess | - |
dc.title | Monoclonal TCR-Vβ13.1+/CD4+/NKa +/CD8-/+dim T-LGL lymphocytosis: Evidence for an antigen-driven chronic T-cell stimulation origin | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1182/blood-2006-05-022277 | - |
dc.date.updated | 2012-12-03T11:56:37Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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