Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/61498
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Sortilin participates in light-dependent photoreceptor degeneration in vivo |
Autor: | Santos, Ana M. C. CSIC ORCID; López-Sánchez, N.; Martín-Oliva, David; Villa, Pedro de la; Cuadros, Miguel A.; Frade López, José María CSIC ORCID | Fecha de publicación: | 2012 | Editor: | Public Library of Science | Citación: | PLoS ONE 7 (2012) | Resumen: | Both proNGF and the neurotrophin receptor p75 (p75 NTR) are known to regulate photoreceptor cell death caused by exposure of albino mice to intense illumination. ProNGF-induced apoptosis requires the participation of sortilin as a necessary p75 NTR co-receptor, suggesting that sortilin may participate in the photoreceptor degeneration triggered by intense lighting. We report here that light-exposed albino mice showed sortilin, p75 NTR, and proNGF expression in the outer nuclear layer, the retinal layer where photoreceptor cell bodies are located. In addition, cone progenitor-derived 661W cells subjected to intense illumination expressed sortilin and p75 NTR and released proNGF into the culture medium. Pharmacological blockade of sortilin with either neurotensin or the >pro> domain of proNGF (pro-peptide) favored the survival of 661W cells subjected to intense light. In vivo, the pro-peptide attenuated retinal cell death in light-exposed albino mice. We propose that an auto/paracrine proapoptotic mechanism based on the interaction of proNGF with the receptor complex p75 NTR/sortilin participates in intense light-dependent photoreceptor cell death. We therefore propose sortilin as a putative target for intervention in hereditary retinal dystrophies. © 2012 Santos et al. | URI: | http://hdl.handle.net/10261/61498 | DOI: | 10.1371/journal.pone.0036243 | Identificadores: | doi: 10.1371/journal.pone.0036243 issn: 1932-6203 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Frade,2012,journal.pone.0036243.pdf | 4,51 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
13
checked on 22-abr-2024
SCOPUSTM
Citations
20
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
18
checked on 28-feb-2024
Page view(s)
308
checked on 24-abr-2024
Download(s)
288
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.