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Guidelines on the appropriate use of animal models for developing therapies in multiple sclerosis

Other TitlesGuía de uso adecuado de modelos animals para el desarrollo de terapias en esclerosis múltiple
AuthorsMoreno, Beatriz; Espejo, Carmen; Mestre, Leyre ; Suardíaz, Margarita; Clemente, Diego; Castro Soubriet, Fernando de ; Fernández-Fernández, Óscar; Montalbán, Xavier; Villoslada, Pablo; Guaza, Carmen
Issue Date2012
PublisherViguera Editores
CitationRevista de Neurologia 54: 114-124 (2012)
AbstractIntroduction. The advance in the achievement of efective therapies for multiple sclerosis (MS), the defnition of appropriate therapeutic windows and to establish better diagnostic and prognostic biomarkers have become a challenging task for both researchers and clinicians. Some pitfalls in clinical trials might be related to lack of adequacy of the preclinical studies in MS experimental animal models. Aim. To standardize the methodological protocols of experimental models by developing a set of guidelines for preclinical studies by groups of experts from REEM (Spanish Network for MS). Development. A guide with recommendations for the application of MS models including a detailed assessment of appropriate experimental models taking into account the objective of the study that has been presented. Standards and quality criteria necessary in a preclinical study have been included. Conclusions. Standardized animal models of MS are essential to increase the success of the preclinical fndings in order to transfer them to the clinical practice. © 2012 Revista de Neurología.
Publisher version (URL)http://doi.org/10.33588/rn.5402.2011424
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