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dc.contributor.authorLeón, Leticia G.-
dc.contributor.authorTejedor, David-
dc.contributor.authorMontero, Juan Carlos-
dc.contributor.authorPandiella, Atanasio-
dc.contributor.authorGarcía-Tellado, Fernando-
dc.contributor.authorPadrón, José M.-
dc.date.accessioned2012-11-28T12:04:10Z-
dc.date.available2012-11-28T12:04:10Z-
dc.date.issued2010-
dc.identifierissn: 0022-2623-
dc.identifiere-issn: 1520-4804-
dc.identifier.citationJournal of Medicinal Chemistry 53(9): 3835-3839 (2010)-
dc.identifier.urihttp://hdl.handle.net/10261/61414-
dc.description.abstractA small structure-focused library of propargylic enol ethers was prepared by means of a modular and efficient chemodifferentiating organocatalyzed multicomponent reaction. The most active compound (GI50 0.25 μM) against solid tumor cells was selected as lead. Cell cycle analysis and immunoblotting demonstrated arrest at the metaphase, pointing out human topoisomerase II as plausible molecular target. In vitro assays were carried out, showing that the lead behaves as a catalytic inhibitor of the enzyme.-
dc.description.sponsorshipFinancial support cofinanced by the EU-FEDER: the Spanish MICIIN (CTQ2008-06806-C02-01/BQU, CTQ2008-06806-C02-02/BQU, and BFU2006-01813/BMC), MSC (RTICC RD06/0020/1046 and RD06/0020/0041); Canary Islands’ ACIISI (PI 2007/021) and FUNCIS (REDESFAC PI 01/06 and 35/06). L.G.L and E.P.R.: Spanish MSC-FIS Sara Borrell contracts. J.M.P.: SpanishMEC-FSE Ramón y Cajal contract.-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.rightsclosedAccess-
dc.titleMitotic arrest induced by a novel family of DNA topoisomerase II inhibitors-
dc.typeartículo-
dc.identifier.doi10.1021/jm100155y-
dc.relation.publisherversionhttp://dx.doi.org/10.1021/jm100155y-
dc.date.updated2012-11-28T12:04:10Z-
dc.description.versionPeer Reviewed-
dc.contributor.funderEuropean Commission-
dc.contributor.funderRed Temática de Investigación Cooperativa en Cáncer (España)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderGobierno de Canarias-
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
dc.contributor.funderFundación Canaria de Investigación y Salud-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100007650es_ES
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