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Title

SU-8 based microprobes with integrated planar electrodes for enhanced neural depth recording

AuthorsAltuna Letamendi, Ane; Menéndez de la Prida, Liset ; Bellistri, Elisa ; Gabriel Buguna, Gemma; Guimera Brunet, Antoni; Berganzo Ruiz, Javier; Villa Sanz, Rosa; Fernández Ledesma, Luis José
Issue Date2012
PublisherElsevier
CitationBiosensors and Bioelectronics 37(1): 1-5 (2012)
AbstractHere, we describe new fabrication methods aimed to integrate planar tetrode-like electrodes into a polymer SU-8 based microprobe for neuronal recording applications. New concepts on the fabrication sequences are introduced in order to eliminate the typical electrode-tissue gap associated to the passivation layer. Optimization of the photolithography technique and high step coverage of the sputtering process have been critical steps in this new fabrication process. Impedance characterization confirmed the viability of the electrodes for reliable neuronal recordings with values comparable to commercial probes. Furthermore, a homogeneous sensing behavior was obtained in all the electrodes of each probe. Finally, . in vivo action potential and local field potential recordings were successfully obtained from the rat dorsal hippocampus. Peak-to-peak amplitude of action potentials ranged from noise level to up to 400-500. μV. Moreover, action potentials of different amplitudes and shapes were recorded from all the four recording sites, suggesting improved capability of the tetrode to distinguish from different neuronal sources. © 2012 Elsevier B.V.
URIhttp://hdl.handle.net/10261/61409
DOI10.1016/j.bios.2012.03.039
Identifiersdoi: 10.1016/j.bios.2012.03.039
issn: 0956-5663
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(IMB-CNM) Artículos
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