Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/61327
Título : Genetic resistance to bovine tuberculosis in the Iberian wild boar
Autor : Acevedo-Whitehouse, Karina, Vicente, J., Gortázar, Christian, Höfle, Ursula, Fernández de Mera, Isabel G., Amos, W.
Fecha de publicación : 2005
Editor: Blackwell Publishing
Citación : Molecular Ecology 14: 3209- 3217 (2005)
Resumen: Bovine tuberculosis (bTB) is an important re-emerging zoonotic disease, causing major economic losses and constraining international trade of animals and their products. Despite eradication programmes, some countries continue to encounter outbreaks, mainly due to wildlife acting as primary hosts or reservoirs. While the genetic component of tuberculosis in humans and cattle is well documented, the role of genetic factors as modulators of bTB resistance remains unclear for natural populations. To address this issue, we investigated the relative contribution of host genetic variability to susceptibility to bTB infection and disease progression in wild boars from southern Spain. We found that genetic heterozygosity is an important predictor of bTB, not only modulating resistance to infection but also influencing containment of disease progression in infected individuals. Our results provide further evidence that host genetic variability plays a central role in natural populations. Testing each marker separately reveals evidence of both general and single-locus associative effects on bTB and several loci reveal high homology to regions of the genome with known immune function. Our results may prove to be crucial for understanding outbreaks of bTB in wildlife that could potentially affect domestic livestock and humans. © 2005 Blackwell Publishing Ltd.
URI : http://hdl.handle.net/10261/61327
Identificadores: doi: 10.1111/j.1365-294X.2005.02656.x
issn: 0962-1083
Appears in Collections:(IREC) Artículos

Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFView/Open
Show full item record
 
CSIC SFX LinksSFX Query

Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.