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Título: | Endocrine-dependent accumulation of IGF-I by hypothalamic glia |
Autor: | Fernández-Galaz, M. C. CSIC; Torres Alemán, Ignacio CSIC ORCID; García-Segura, Luis M. CSIC ORCID | Fecha de publicación: | 1997 | Editor: | Lippincott Williams & Wilkins | Citación: | NeuroReport 8: 373- 377 (1997) | Resumen: | Tanycytes are specialized glial cells of the hypothalamus and median eminence. Immunoreactive insulin-like growth factor I (IGF-I) levels fluctuate in tanycytes with the natural variations in sex steroids associated with the ovarian cycle. To determine whether these changes are of differences in IGF-I accumulation, the peptide was labelled with digoxigenin and injected into the lateral cerebral ventricle. Tanycyte-like cells specifically accumulated digoxigenin-labelled IGF-I. This accumulation was mediated by IGF-I receptors and showed marked differences during the oestrous cycle, being low in the afternoon of pro-oestrus and high in-the afternoon of oestrus. These results indicate that the accumulation by tanycytes of IGF-I or IGF-I fragments capable of receptor-mediated internalization is under endocrine control, suggesting that hypothalamic glia may be involved in neuroendocrine regulation. | URI: | http://hdl.handle.net/10261/61229 | ISSN: | 0959-4965 |
Aparece en las colecciones: | (IC) Artículos |
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