English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/60913
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Sexual dimorphism in the early life programming of serum leptin levels in European adolescents: The HELENA study

AuthorsLabayen, Idoia; Ruiz, Jonatan R.; Huybrechts, Inge; Ortega, F. B.; Rodríguez, Gerardo; De Henauw, Stefaan; Breidenassel, C.; Jiménez-Pavón, D.; Vyncke, K. E.; Censi, Laura; Molnar, Denes; Widhalm, Kurt; Kafatos, Anthony; Plada, M.; Díaz, L. E. ; Marcos, Ascensión ; Moreno, Luis A.; Gottrand, Frederic
Issue Date2011
PublisherEndocrine Society
CitationJournal of Clinical Endocrinology and Metabolism 96: E1330- E1334 (2011)
AbstractAim: The aim of this study was to test the hypothesis that a lower birth weight, as an indicator of adverse intrauterine environment, is associated with higher serum leptin levels in European adolescents. We also examined the possible sexual dimorphism in this relationship. Methods: Fasting serum leptin was measured in 757 European born at term adolescents (429 females) aged 14.6 ± 1.2 yr. We measured weight and height, and body mass index was calculated. Birth weight, duration of pregnancy, and duration of breast-feeding were obtained from parental records. Duration of pregnancy and breast-feeding, pubertal status, center, body mass index, and physical activity were entered as confounders in the analyses. Results: There was a significant interaction effect between sex and birth weight on serum leptin levels (P = 0.044). We observed that body weight at birth was negatively and significantly associated with serum leptin levels only in female adolescents (β = -0.109; adjusted P = 0.008). The association persisted after further controlling for physical activity (β = -0.115; adjusted P = 0.016). Conclusions: These findings provide further evidence for a sex-specific programming effect of birth weight on serum leptin levels. Our results also contribute to explain the detrimental health effects associated with lower birth weight, such as long-term increased risk of developing obesity and type 2 diabetes. Copyright © 2011 by The Endocrine Society.
URIhttp://hdl.handle.net/10261/60913
DOI10.1210/jc.2011-1036
Identifiersdoi: 10.1210/jc.2011-1036
issn: 0021-972X
Appears in Collections:(ICTAN) Artículos
Files in This Item:
File Description SizeFormat 
Sexual dimorphism.pdf220,14 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.