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Título: | Cyclooxygenase-2 -765G>C polymorphism is associated with C-reactive protein levels in resistant smokers but not in chronic obstructive pulmonary disease patients |
Autor: | López-Campos, J. L. CSIC ORCID; Montes-Worboys, Ana; Calero-Acuña, Carmen CSIC; Márquez-Martín, Eduardo CSIC ORCID CVN; Cejudo, Pilar CSIC ORCID; Ortega-Ruiz, Francisco CSIC ORCID; Arellano-Orden, Elena CSIC ORCID | Fecha de publicación: | 2012 | Editor: | Elsevier | Citación: | Respiratory Physiology and Neurobiology 180: 119- 125 (2012) | Resumen: | We sought to investigate whether the serum concentrations of several inflammatory biomarkers are related to the cyclooxygenase-2 (COX2) - 765G>C polymorphism in chronic obstructive pulmonary disease (COPD) and a control group of non-COPD smokers. Serum inflammatory markers (CRP, SAA, CXCL8, and sICAM-1) were measured by ELISA in 144 patients with COPD and in 55 control subjects. Genomic DNA was extracted from peripheral blood leukocytes, and the COX2 - 765G>C (rs20417) polymorphism was genotyped. After adjustment for age and active smoking, CRP and SAA concentrations were associated with the COX2 polymorphism in controls (p= 0.041 and 0.014, respectively) but not in COPD patients. The CXCL8 and sICAM-1 concentrations were not associated with the COX2 polymorphism for either cases or controls. The results of the present study indicate that there is a relationship between the COX2 - 765G>C polymorphism and the concentrations of CRP and SAA in non-COPD smokers and that this relationship does not exist in COPD patients. © 2011 Elsevier B.V. | URI: | http://hdl.handle.net/10261/60866 | DOI: | 10.1016/j.resp.2011.11.001 | Identificadores: | doi: 10.1016/j.resp.2011.11.001 issn: 1569-9048 |
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