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Título: | Oscillations and temporal signalling in cells |
Autor: | Tiana, Guido; Krishna, Sandeep; Pigolotti, Simone CSIC; Jensen, Mogens H.; Sneppen, K. | Palabras clave: | Molecular Networks Quantitative Biology |
Fecha de publicación: | 18-may-2007 | Editor: | Institute of Physics Publishing | Citación: | Physical Biology 4, R1-R17 (2007) | Resumen: | The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration using a framework of simple mathematical models. We focus on three eukaryotic genetic regulatory networks which show ultradian oscillations, with a time period of the order of hours, and involve, respectively, proteins important for development (Hes1), apoptosis (p53) and immune response (NF-κB). We argue that underlying all three is a common design consisting of a negative feedback loop with time delay which is responsible for the oscillatory behaviour. | Descripción: | ArXiv pre-print: http://arxiv.org/abs/q-bio/0703047.-- Final full-text version of the paper available at: http://dx.doi.org/10.1088/1478-3975/4/2/R01. PMID: 17664651 |
URI: | http://hdl.handle.net/10261/6083 | DOI: | 10.1088/1478-3975/4/2/R01 | ISSN: | 1478-3975 (Online) |
Aparece en las colecciones: | (IFISC) Artículos |
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Pigo_physbio.pdf | 539,73 kB | Adobe PDF | Visualizar/Abrir |
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