Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/60791
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice |
Autor: | Gómez-Nicola, Diego CSIC ORCID; Spagnolo, Alessandra CSIC; Guaza, Carmen CSIC ORCID ; Nieto-Sampedro, Manuel CSIC | Fecha de publicación: | 2010 | Editor: | Academic Press | Citación: | Experimental Neurology 222: 235- 242 (2010) | Resumen: | IL-15 initially identified as a T proliferating cytokine has several structural and biological similarities with IL-2 and has been associated with a number of autoimmune diseases. Because of the scarcity of information available on the role of IL-15 in MS pathogenesis, we have investigated how the absence of IL-15 affected the development of experimental autoimmune encephalomyelitis, a mouse model of MS. Following immunization of IL-15-/- and C57BL/6 mice with MOG35-55, we observed a more severe neurological impairment in the IL-15 knockout mice than in the wild-type group. The enhanced disease severity in IL-15-/- mice was associated with greater demyelination in the spinal cord, increased immune cell infiltration and inflammation. These events may be related to the higher CD4/CD8 ratio and the almost absent NK cell activity, congenital immune features of IL-15KO mice. Moreover, we found that the fractalkine receptor CX3CR1 was overexpressed in the spinal cord of IL-15-/- mice, mainly localized on infiltrating CD8+ T cells. How these findings are contributing to the aggravated EAE development in IL-15 KO mice remain unclear and need to be further investigated. © 2009 Elsevier Inc. All rights reserved. | URI: | http://hdl.handle.net/10261/60791 | DOI: | 10.1016/j.expneurol.2009.12.034 | Identificadores: | doi: 10.1016/j.expneurol.2009.12.034 issn: 0014-4886 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
29
checked on 23-mar-2024
WEB OF SCIENCETM
Citations
29
checked on 28-feb-2024
Page view(s)
324
checked on 29-mar-2024
Download(s)
133
checked on 29-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.