English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/60684
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Interaction between clonal plasma cells and the immune system in plasma cell dyscrasias

AuthorsPérez-Andrés, Martin; Almeida, Julia ; Martín-Ayuso, Marta; García-Marcos, M. A.; San Miguel, Jesús F. ; Orfao, Alberto
Issue Date2004
PublisherWichtig Editore
CitationJournal of Biological Regulators and Homeostatic Agents 18(2): 161-165 (2004)
AbstractThe term >monoclonal gammopathy> (MG) includes a group of clonal plasma cell disorders, which show heterogeneous clinical behavior. While multiple myeloma (MM) and plasma cell leukemia (PCL) are incurable malignant diseases, most patients with MG of undetermined significance (MGUS) show an indolent/benign clinical course. Evidence has accumulated which supports the role of the bone marrow microenvironment in MG. Accordingly, the survival, drug-resistance and proliferation of MM cells have been shown to be largely dependent on a supportive microenvironment. Among the different environment-associated parameters, those related to the status/activity of the immune system are particularly relevant. This review focuses on the different ways clonal plasma cells (PC) interact with the immune system in different models of MG, to characterize crucial events in the development and progression of MG. These advances may support the design of novel therapeutic approaches in patients with MG. © Wichtig Editore, 2004.
Identifiersissn: 0393-974X
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.