Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/60478
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | High-resolution genome-wide analysis of chromosomal alterations in elastofibroma |
Autor: | García, Juan L. CSIC ORCID CVN ; Benito, Rocío; Hernández, Jesús M. CSIC ORCID | Fecha de publicación: | 2010 | Editor: | Springer Nature | Citación: | Virchows Archiv 456: 681-687 (2010) | Resumen: | Elastofibroma is a rare, benign fibrous proliferation that most commonly occur in periscapular soft tissues and is characterized by accumulated elastic fibers. Although the lesion is generally regarded as a reactive process, an unusual fibroblastic pseudotumor or as a fibroelastic tumor-like lesion, its etiology remains unknown. Cytogenetic studies in these lesions detected chromosomal instability and some recurrent clonal chromosomal changes, which raised the possibility that the lesion represents a neoplastic process. Here, we report the genomic alterations detected by array-based comparative genomic hybridization (aCGH) and by multiplex ligationdependent probe amplification (MLPA) in two cases of elastofibroma. Both cases showed losses on 1p, 13q, 19p, and 22q by aCGH. In addition, deletion of CASR (3q21), GSTP1 (11q13), BRCA2 (13q12) and gains on APC (5q21) and PAH (12q23) were observed by MLPA in both samples. Genomic screening studies of this fibrous proliferation may lead to identify chromosomal regions containing genes involved in the development of elastofibromas. © Springer-Verlag 2010. | URI: | http://hdl.handle.net/10261/60478 | DOI: | 10.1007/s00428-010-0911-y | Identificadores: | doi: 10.1007/s00428-010-0911-y issn: 0945-6317 e-issn: 1432-2307 |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
18
checked on 24-mar-2024
WEB OF SCIENCETM
Citations
15
checked on 29-feb-2024
Page view(s)
341
checked on 29-mar-2024
Download(s)
109
checked on 29-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.