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High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics

AuthorsSantamaría, Carlos; Chillón, M. del Carmen; García-Sanz, Ramón; Caballero, Maria Dolores; Sarasquete, María Eugenia; Díaz-Mediavilla, J.; San Miguel, Jesús F. ; González, Marcos
Issue Date2009
CitationLeukemia Research 33(12): 1706-1709 (2009)
AbstractThe PI3/AKT pathway is up-regulated in acute myeloid leukemia (AML), but its prognostic relevance in cytogenetically normal AML (CN-AML) is unclear. We evaluated RNA levels of AKT and two downstream substrates (FOXO3a-p27) in 110 de novo CN-AML, included in the Spanish PETHEMA therapeutic protocols. Patients with high FOXO3a gene expression displayed shorter OS (p = 0.015) and RFS (p = 0.048) than low FOXO3a expressers. Features selected in the multivariate analysis as having an independent prognostic value for a shorter survival were WBC > 50 × 109/L, age >65 years and high FOXO3a expression. We concluded that FOXO3a assessment could contribute to improve the molecular-based risk stratification in CN-AML. © 2009 Elsevier Ltd. All rights reserved.
Identifiersdoi: 10.1016/j.leukres.2009.04.024
issn: 0145-2126
Appears in Collections:(IBMCC) Artículos
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