Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/60358
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Hernangómez-Herrero, Miriam | - |
dc.contributor.author | Mestre, Leyre | - |
dc.contributor.author | Correa, Fernando Gabriel | - |
dc.contributor.author | Loría, Frida | - |
dc.contributor.author | Mecha, Miriam | - |
dc.contributor.author | Ínigo, Paula M. | - |
dc.contributor.author | Docagne, Fabian | - |
dc.contributor.author | Williams, R. O. | - |
dc.contributor.author | Borrell, José | - |
dc.contributor.author | Guaza, Carmen | - |
dc.date.accessioned | 2012-11-15T15:18:26Z | - |
dc.date.available | 2012-11-15T15:18:26Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier | doi: 10.1002/glia.22366 | - |
dc.identifier | issn: 0894-1491 | - |
dc.identifier.citation | Glia 60(9): 1437-1450 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/60358 | - |
dc.description.abstract | The endocannabinoid anandamide (AEA) is released by macrophages and microglia on pathological neuroinflammatory conditions such as multiple sclerosis (MS). CD200 is a membrane glycoprotein expressed in neurons that suppresses immune activity via its receptor (CD200R) mainly located in macrophages/microglia. CD200-CD200R interactions contribute to the brain immune privileged status. In this study, we show that AEA protects neurons from microglia-induced neurotoxicity via CD200-CD200R interaction. AEA increases the expression of CD200R1 in LPS/IFN-γ activated microglia through the activation of CB 2 receptors. The neuroprotective effect of AEA disappears when microglial cells derive from CD200R1 -/- mice. We also show that engagement of CD200R1 by CD200Fc decreased the production of the proinflammatory cytokines IL-1β and IL-6, but increased IL-10 in activated microglia. In the chronic phases of Theiler's virus-induced demyelinating disease (TMEV-IDD) the expression of CD200 and CD200R1 was reduced in the spinal cord. AEA-treated animals up-regulated the expression of CD200 and CD200R1, restoring levels found in sham animals together with increased expression of IL-10 and reduced expression of IL-1β and IL-6. Treated animals also improved their motor behavior. Because AEA up-regulated the expression of CD200R1 in microglia, but failed to enhance CD200 in neurons we suggest that AEA-induced up-regulation of CD200 in TMEV-IDD is likely due to IL-10 as this cytokine increases CD200 in neurons. Our findings provide a new mechanism of action of AEA to limit immune response in the inflamed brain. © 2012 Wiley Periodicals, Inc. | - |
dc.description.sponsorship | M. Hernangómez is a predoctoral fellow from the Spanish Ministerio de Ciencia e Innovación. | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons | - |
dc.rights | closedAccess | - |
dc.title | CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1002/glia.22366 | - |
dc.date.updated | 2012-11-15T15:18:27Z | - |
dc.description.version | Peer Reviewed | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
102
checked on 12-abr-2024
WEB OF SCIENCETM
Citations
92
checked on 27-feb-2024
Page view(s)
371
checked on 19-abr-2024
Download(s)
187
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.