Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/60229
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Biogenic amine production by the wine Lactobacillus brevis IOEB 9809 in systems that partially mimic the gastrointestinal tract stress

AutorRusso, Pasquale; Fernández de Palencia, P. CSIC; Romano, Andrea; Fernández García, María CSIC ORCID ; Lucas, Patrick; Spano, Giuseppe; López García, Paloma CSIC ORCID
Fecha de publicación31-oct-2012
EditorBioMed Central
CitaciónBMC Microbiology. 12(1):247 (2012)
ResumenAbstract Background Ingestion of fermented foods containing high levels of biogenic amines (BA) can be deleterious to human health. Less obvious is the threat posed by BA producing organisms contained within the food which, in principle, could form BA after ingestion even if the food product itself does not initially contain high BA levels. In this work we have investigated the production of tyramine and putrescine by Lactobacillus brevis IOEB 9809, of wine origin, under simulated gastrointestinal tract (GIT) conditions. Results An in vitro model that simulates the normal physiological conditions in the human digestive tract, as well as Caco-2 epithelial human cell lines, was used to challenge L. brevis IOEB 9809, which produced both tyramine and putrescine under all conditions tested. In the presence of BA precursors and under mild gastric stress, a correlation between enhancement of bacterial survival and a synchronous transcriptional activation of the tyramine and putrescine biosynthetic pathways was detected. High levels of both BA were observed after exposure of the bacterium to Caco-2 cells. Conclusions L. brevis IOEB 9809 can produce tyramine and putrescine under simulated human digestive tract conditions. The results indicate that BA production may be a mechanism that increases bacterial survival under gastric stress.
Versión del editorhttp://dx.doi.org/10.1186/1471-2180-12-247
URIhttp://hdl.handle.net/10261/60229
DOI10.1186/1471-2180-12-247
ISSN1471-2180
E-ISSN1471-2180
Aparece en las colecciones: (CIB) Artículos
(IPLA) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
1471-2180-12-247.xml77,03 kBXMLVisualizar/Abrir
1471-2180-12-247.pdf676,71 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

PubMed Central
Citations

10
checked on 03-mar-2024

SCOPUSTM   
Citations

28
checked on 13-mar-2024

WEB OF SCIENCETM
Citations

28
checked on 23-feb-2024

Page view(s)

413
checked on 18-mar-2024

Download(s)

434
checked on 18-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.