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Open Access item Arabidopsis thaliana telomeres exhibit euchromatic features

Authors:Vaquero-Sedas, M.I.
Gámez-Arjona, Francisco M.
Vega-Palas, M.A.
Issue Date:Nov-2010
Publisher:Oxford University Press
Citation:Nucleic acids research 39 (6): 2007-2017 (2011)
Abstract:Telomere function is influenced by chromatin structure and organization, which usually involves epigenetic modifications. We describe here the chromatin structure of Arabidopsis thaliana telomeres. Based on the study of six different epigenetic marks we show that Arabidopsis telomeres exhibit euchromatic features. In contrast, subtelomeric regions and telomeric sequences present at interstitial chromosomal loci are heterochromatic. Histone methyltransferases and the chromatin remodeling protein DDM1 control subtelomeric heterochromatin formation. Whereas histone methyltransferases are required for histone H3K92Me and non-CpG DNA methylation, DDM1 directs CpG methylation but not H3K92Me or non-CpG methylation. These results argue that both kinds of proteins participate in different pathways to reinforce subtelomeric heterochromatin formation.
Description:11 pages
Publisher version (URL):http:dx.doi.org/10.1093/nar/gkq1119
URI:http://hdl.handle.net/10261/60115
ISSN:0305-1048
E-ISSNmetadata.dc.identifier.doi = DOI:1362-4962
Appears in Collections:(IBVF) Artículos

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