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Registro de acceso abierto Arabidopsis thaliana telomeres exhibit euchromatic features

Autor :Vaquero-Sedas, M.I.
Gámez-Arjona, Francisco M.
Vega-Palas, M.A.
Fecha de publicación :2011
Editor:Oxford University Press
Citación :Nucleic Acids Research 39: 2007- 2017 (2011)
Resumen :Telomere function is influenced by chromatin structure and organization, which usually involves epigenetic modifications. We describe here the chromatin structure of Arabidopsis thaliana telomeres. Based on the study of six different epigenetic marks we show that Arabidopsis telomeres exhibit euchromatic features. In contrast, subtelomeric regions and telomeric sequences present at interstitial chromosomal loci are heterochromatic. Histone methyltransferases and the chromatin remodeling protein DDM1 control subtelomeric heterochromatin formation. Whereas histone methyltransferases are required for histone H3K9 2Me and non-CpG DNA methylation, DDM1 directs CpG methylation but not H3K92Me or non-CpG methylation. These results argue that both kinds of proteins participate in different pathways to reinforce subtelomeric heterochromatin formation. © The Author(s) 2010. Published by Oxford University Press.
URI :http://hdl.handle.net/10261/60109
Identificadores:doi: 10.1093/nar/gkq1119
issn: 0305-1048
e-issn: 1362-4962
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