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Title

CLL-like B-lymphocytes are systematically present at very low numbers in peripheral blood of healthy adults

AuthorsAlmeida, Julia ; Teodosio, Cristina; Pedreira, C. E.; López, Antonio; Nieto, Ana B.; Rodríguez-Caballero, Arancha; Jara-Acevedo, Maria; Orfao, Alberto
Issue Date2011
PublisherNature Publishing Group
CitationLeukemia 25: 718- 722 (2011)
AbstractChronic lymphocytic leukemia (CLL) is the most common type of leukemia in the Western world. The disease is typically diagnosed in adults >40 years old, who show an expansion (>5 × 109 cells per l) of clonal B-cells with a unique CD5+, CD23+, B-cell receptor (BCR)low immunophenotype in peripheral blood (PB) and bone marrow, frequently in association with involvement of other lymphoid tissues, disease symptoms and a heterogeneous clinical outcome.
URIhttp://hdl.handle.net/10261/59816
DOI10.1038/leu.2010.305
Identifiersdoi: 10.1038/leu.2010.305
issn: 0887-6924
e-issn: 1476-5551
Appears in Collections:(IBMCC) Artículos
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