English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/59790
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
DC FieldValueLanguage
dc.contributor.authorLaso, Francisco Javier-
dc.contributor.authorAlmeida, Julia-
dc.contributor.authorTorres, Emiliano-
dc.contributor.authorVaquero, José Miguel-
dc.contributor.authorMarcos, Miguel-
dc.contributor.authorOrfao, Alberto-
dc.date.accessioned2012-11-08T09:30:32Z-
dc.date.available2012-11-08T09:30:32Z-
dc.date.issued2010-
dc.identifierdoi: 10.1111/j.1530-0277.2010.01160.x-
dc.identifierissn: 0145-6008-
dc.identifiere-issn: 1530-0277-
dc.identifier.citationAlcoholism: Clinical and Experimental Research 34(5): 876-885 (2010)-
dc.identifier.urihttp://hdl.handle.net/10261/59790-
dc.description.abstract[Background]: Apoptosis has recently emerged as a key component of acute and chronic liver diseases and it could be related to alcoholic liver disease. In the present study, we attempted to analyze the cytotoxic profile of circulating lymphocytes in chronic alcoholic patients grouped according to ethanol intake status and presence of liver disease. [Methods]: We investigate the phenotypic and functional behavior of different compartments of peripheral blood (PB) cytotoxic T and natural killer (NK) cells in chronic alcoholic patients without liver disease and active ethanol intake (AWLD group; n = 22), and in subjects with alcohol liver cirrhosis (ALC group; n = 22). [Results]: AWLD patients showed an expansion of both CD4+/CD8+ cytotoxic T cells and NK/T cells, in association with an enhanced cytolytic activity against K562 cells and a higher ability to induce in vitro expression of the pro-apoptotic protein APO2.7 in HepG2 cells. Conversely, ethanol intake in ALC patients was associated with decreased NK cell numbers, a reduced cytotoxic activity against K562 cells without significant changes in the expression of APO2.7, and a pro-fibrotic profile of cytokine secretion. [Conclusions]: Overall, our results suggest that alcoholic patients display different phenotypical and functional changes in circulating PB cytotoxic lymphocytes according to the presence of alcoholic liver disease, which could be related to the development and progress of liver injury.-
dc.description.sponsorshipSupported by an Institutional Grant (FIS 99/1239) from the Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, and an Institutional Grant (MSC 2007/020) from the Plan Nacional sobre Drogas, Ministerio de Sanidad y Consumo, Madrid, Spain. -
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.rightsclosedAccess-
dc.titleChronic Alcohol Consumption Is Associated With an Increased Cytotoxic Profile of Circulating Lymphocytes That May Be Related With the Development of Liver Injury-
dc.typeArtículo-
dc.identifier.doi10.1111/j.1530-0277.2010.01160.x-
dc.date.updated2012-11-08T09:30:32Z-
dc.description.versionPeer Reviewed-
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.