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Título: | Characterization and gene expression analysis of the two main Th17 cytokines (IL-17A/F and IL-22) in turbot, Scophthalmus maximus |
Autor: | Costa, M. M. CSIC ORCID; Pereiro, Patricia CSIC ORCID; Wang, Tiehui; Secombes, Christopher J.; Figueras Huerta, Antonio CSIC ORCID ; Novoa, Beatriz CSIC ORCID | Palabras clave: | IL-22 IL-17 Th-17 response Mucosal-associated immunity |
Fecha de publicación: | 2012 | Editor: | Elsevier | Citación: | Developmental and Comparative Immunology 38(4): 505-516 (2012) | Resumen: | This report describes the cloning, characterization and gene expression pattern of two Th17 cytokines, interleukin (IL)-17A/F and -22, in turbot Scophthalmus maximus. The turbot IL-17A/F cDNA contains a 516 bp open reading frame encoding a deduced IL-17A/F protein of 171 amino acid (aa) residues, containing a predicted signal peptide of 31 aa. Turbot IL-22 had a 564 bp ORF coding for a 187 aa protein with a 33 aa signal peptide. The turbot IL-22 protein contained a typical IL-10 family signature. Both cytokines had highest expression levels in the intestine followed by head kidney and gills. Stimulation with the Gram negative bacterium Aeromonas salmonicida was able to modulate IL-17A/F and IL-22 expression in head kidney, spleen and liver but not the intestine. PMA and PHA were also able to induce the expression of both cytokines, suggesting that, as expected, T-cells are likely the main producers of these molecules in turbot as in mammals. | Descripción: | 12 páginas, 8 figuras, 3 tablas | Versión del editor: | http://dx.doi.org/10.1016/j.dci.2012.09.002 | URI: | http://hdl.handle.net/10261/59774 | DOI: | 10.1016/j.dci.2012.09.002 | ISSN: | 0145-305X | E-ISSN: | 1879-0089 |
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Characterization_gene_expression.pdf | 632,43 kB | Adobe PDF | Visualizar/Abrir |
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