Nucleic acids encoding prrsv gp5-ecto domain and m protein

Abstract

The present invention relates to nucleic acids comprising: (a) a sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:I (sequence ofthe GP5 ecto-domain ofthe European strain ofPRRSV) or a sequence having at least 85% identity to SEQ ID NO: 1, which sequence includes at least one amino acid capable offorming a disulfide bridge; and (b) a sequence encoding a polypeptide comprising the amino acid sequence SEQ ID NO: 2 (sequence of the GP5 M protein of the European strain of PRRSV) or a sequence having at least 85% identity to SEQ ID NO: 2; (c) wherein the nucleic acid does not comprise a sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 3 (sequence ofthe GP5 protein except the ecto-domain ofthe European strain of PRRSV) or a sequence having at least 80% identity to SEQ ID NO: 3. The present invention further provides respective nucleic acids from other strains of PRRSV and their use as a vaccine for the treatment of animals.