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Open Access item Nucleic acids encoding prrsv gp5-ecto domain and m protein

Authors:Enjuanes Sánchez, Luis
Becares, Martina
Plana Durán, Juan
Zúñiga Lucas, Sonia
Issue Date:31-May-2012
Citation:WO2012069638 A1
Abstract:The present invention relates to nucleic acids comprising: (a) a sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:I (sequence ofthe GP5 ecto-domain ofthe European strain ofPRRSV) or a sequence having at least 85% identity to SEQ ID NO: 1, which sequence includes at least one amino acid capable offorming a disulfide bridge; and (b) a sequence encoding a polypeptide comprising the amino acid sequence SEQ ID NO: 2 (sequence of the GP5 M protein of the European strain of PRRSV) or a sequence having at least 85% identity to SEQ ID NO: 2; (c) wherein the nucleic acid does not comprise a sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 3 (sequence ofthe GP5 protein except the ecto-domain ofthe European strain of PRRSV) or a sequence having at least 80% identity to SEQ ID NO: 3. The present invention further provides respective nucleic acids from other strains of PRRSV and their use as a vaccine for the treatment of animals.
URI:http://hdl.handle.net/10261/59746
Appears in Collections:(CNB) Patentes

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