Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/59649
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Control of neuronal ploidy during vertebrate development |
Autor: | López-Sánchez, Noelia CSIC ORCID; Ovejero-Benito, M. C. CSIC ORCID; Borreguero, Lucía CSIC; Frade López, José María CSIC ORCID | Fecha de publicación: | 2011 | Editor: | Springer Nature | Citación: | Results and Problems in Cell Differentiation 53: 547- 563 (2011) | Resumen: | Somatic tetraploid neurons are present in different structures of the vertebrate nervous system, including cortex and retina. In this chapter, we provide evidence that these neurons can be widely detected in the chick nervous system. We also discuss mechanisms creating neuronal tetraploidy in vertebrates, concluding that the neurotrophin receptor p75 could be responsible for the generation of these neurons in most neural tissues, as previously observed in the retina. Somatic tetraploidy in the chick retina correlates with increased neurons' soma size and dendritic arborization, giving rise to neurons known to innervate a specific layer of the optic tectum. Tetraploidy could therefore account for neuronal diversity in the normal nervous system. De novo generation of tetraploid neurons has been shown to occur in Alzheimer's disease. This suggests that the morphological changes expected to occur in the affected neurons could lead to altered neuronal function, thus providing a basis for neurodegeneration. © 2011 Springer-Verlag Berlin Heidelberg. | URI: | http://hdl.handle.net/10261/59649 | DOI: | 10.1007/978-3-642-19065-0_22 | Identificadores: | doi: 10.1007/978-3-642-19065-0_22 issn: 0080-1844 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
13
checked on 13-abr-2024
WEB OF SCIENCETM
Citations
12
checked on 27-feb-2024
Page view(s)
305
checked on 16-abr-2024
Download(s)
114
checked on 16-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.