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Title: | Cloneable marker for use in microscopy |
Other Titles: | Marcador clonable para su uso en microscopía | Authors: | Risco, Cristina; Sanmartín, Eva | Issue Date: | 21-Jun-2012 | Citation: | WO2012080551 A1 | Abstract: | [EN] The invention relates to a peptide that can be used as a cloneable marker for the detection of proteins of interest by means of microscopy, preferably electronic or correlative microscopy, in which the design of the amino acid sequence has been
based on the skeleton of cysteines from the metallothionein (MT) sequence, but where the remaining amino acids have been substituted with small amino acids with no charge. The invention also relates to smaller fragments of the above-mentioned peptide and to the use thereof in the detection of proteins of interest by means of microscopy, preferably electronic or correlative, as well as to a method for the detection of proteins of interest by means of microscopy, preferably electronic or correlative, comprising the use of said peptide or the fragments thereof. [ES] La presente invención proporciona un péptido útil como marcador clonable para la detección de proteinas de interés por microscopía, preferiblemente electrónica o correlativa, cuya secuencia aminoacídica ha sido diseñada en base al esqueleto de cisteinas de la secuencia de la metalotioneína (MT) pero donde el resto de los aminoácidos han sido sustituidos por aminoácidos de pequeño tamaño sin carga. La invención también se refiere a fragmentos de menor tamaño de dicho péptido de la invención y a su uso en la detección de proteínas de interés por microscopía, preferiblemente electrónica o correlativa, así como a un método de detección de proteínas de interés por microscopía, preferiblemente electrónica o correlativa, que comprende el uso de este péptido o de sus fragmentos. |
URI: | http://hdl.handle.net/10261/59442 |
Appears in Collections: | (CNB) Patentes |
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WO2012080551A1.pdf | 3,26 MB | Adobe PDF | View/Open |
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