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Title

Advances and perspectives of the architecture of hemidesmosomes: Lessons from structural biology

AuthorsPereda, José M. de ; Ortega, Esther ; Alonso-García, Noelia ; Gómez-Hernández, María
Issue Date2009
PublisherLandes Bioscience
CitationCell Adhesion and Migration 3(4): 361-364 (2009)
AbstractHemidesmosomes (HD) are adhesive protein complexes that mediate stable attachment of basal epithelial cells to the underlying basement membrane. The organization of HDs relies on a complex network of protein-protein interactions, in which integrin ¿6ß4 and plectin play an essential role. Here we summarize the current knowledge of the structure of hemidesmosomal proteins, which includes the structures of the first and second fibronectin type III (FnIII) domains and the calx-ß domain of the integrin ß4 subunit, the actin binding domain of plectin, and two non-overlapping pairs of spectrin repeats of plectin and BPAG1e. Binding of plectin to the ß4 subunit is critical for the formation and the stability of HDs. The recent 3D structure of the primary complex between the integrin ß4 subunit and plectin has provided a first insight into the macromolecular recognition mechanisms responsible for HD assembly. Two missense mutations in ß4 linked to non lethal forms of epidermolysis bullosa map on the plectin-binding surface. Finally, the formation of the ß4-plectin complex induces conformational changes in ß4 and plectin, suggesting that their interaction may be subject to allosteric regulation.
URIhttp://hdl.handle.net/10261/59184
DOI10.4161/cam.3.4.9525
Identifiersdoi: 10.4161/cam.3.4.9525
issn: 1933-6918
e-issn: 1933-6926
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