Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/59112
Título : Activated growth signaling pathway expression in Ewing sarcoma and clinical outcome
Autor : Mora, Jaume, Rodríguez, Eva, Torres, Carmen de, Ríos, José, Hernández, M. Teresa, Álava, Enrique de
Fecha de publicación : 2012
Editor: Wiley-Blackwell
Citación : Pediatric Blood and Cancer 58(4): 532-538 (2012)
Resumen: [Background]: In Ewing sarcoma (EWS) most of the research on signaling pathways has been performed on cell lines or animal models. The objective of the current study was to determine the relation between clinical outcome and the expression of proteins involved in active growth signaling pathways. [Methods]: A paraffin-embedded microarray of 45 human primary EWS tissue specimens was stained with the antibodies against c-KIT, AKT, p-AKT, p-mTOR, IGF-1R, IGFBP-3, MAPK, p27 KIP1, and p70S6 kinase. Immunohistochemical staining was correlated with patient overall survival (OS). [Results]: In the univariate analysis 3 variables showed statistical significance to predict survival: presence of metastasis, p-mTOR, and p27 KIP1. A positive stain for p-mTOR (hazard ratio of 4.74 [95% CI (57, 121)]) was significantly (log-rank test with a P=0.029) associated with better OS. Also, a positive stain for p27 KIP1 (hazard ratio of 6.87 [95% CI (77, 136)] was significantly (log-rank test with a P=0.009) associated with better OS. Multivariate analysis showed metastasis (HR: 4.3; 95% CI: 0.99, 19; P=0.05), p-mTOR (HR: 4.8 with 95% CI: 0.6, 38; P=0.13) and p27 (HR: 5.3; 95% CI: 1.37, 20; P=0.01) as independent prognostic factors of outcome. [Conclusions]: In our series, p-mTOR and p27 KIP1 protein overexpression were independently associated with better survival. © 2011 Wiley Periodicals, Inc.
Descripción : 7 páginas, 4 figuras, 1 tabla.-- et al.
URI : http://hdl.handle.net/10261/59112
Identificadores: doi: 10.1002/pbc.23348
issn: 1545-5009
e-issn: 1545-5017
Appears in Collections:(IBMCC) Artículos

Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFView/Open
Show full item record
 
CSIC SFX LinksSFX Query

Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.