English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/59112
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Activated growth signaling pathway expression in Ewing sarcoma and clinical outcome

AuthorsMora, Jaume; Rodríguez, Eva; Torres, Carmen de; Cardesa, Teresa; Ríos, José; Hernández, M. Teresa ; Cardesa, Antonio; Álava, Enrique de
Issue Date2012
PublisherWiley-Blackwell
CitationPediatric Blood and Cancer 58(4): 532-538 (2012)
Abstract[Background]: In Ewing sarcoma (EWS) most of the research on signaling pathways has been performed on cell lines or animal models. The objective of the current study was to determine the relation between clinical outcome and the expression of proteins involved in active growth signaling pathways. [Methods]: A paraffin-embedded microarray of 45 human primary EWS tissue specimens was stained with the antibodies against c-KIT, AKT, p-AKT, p-mTOR, IGF-1R, IGFBP-3, MAPK, p27 KIP1, and p70S6 kinase. Immunohistochemical staining was correlated with patient overall survival (OS). [Results]: In the univariate analysis 3 variables showed statistical significance to predict survival: presence of metastasis, p-mTOR, and p27 KIP1. A positive stain for p-mTOR (hazard ratio of 4.74 [95% CI (57, 121)]) was significantly (log-rank test with a P=0.029) associated with better OS. Also, a positive stain for p27 KIP1 (hazard ratio of 6.87 [95% CI (77, 136)] was significantly (log-rank test with a P=0.009) associated with better OS. Multivariate analysis showed metastasis (HR: 4.3; 95% CI: 0.99, 19; P=0.05), p-mTOR (HR: 4.8 with 95% CI: 0.6, 38; P=0.13) and p27 (HR: 5.3; 95% CI: 1.37, 20; P=0.01) as independent prognostic factors of outcome. [Conclusions]: In our series, p-mTOR and p27 KIP1 protein overexpression were independently associated with better survival. © 2011 Wiley Periodicals, Inc.
Description7 páginas, 4 figuras, 1 tabla.-- et al.
URIhttp://hdl.handle.net/10261/59112
DOI10.1002/pbc.23348
Identifiersissn: 1545-5009
e-issn: 1545-5017
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.