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dc.contributor.authorBogdanovic, Ozren-
dc.contributor.authorDelfino-Machín, Mariana-
dc.contributor.authorNicolás-Pérez, María-
dc.contributor.authorGavilán, María P.-
dc.contributor.authorGago-Rodrigues, Inês-
dc.contributor.authorFernández-Miñán, Ana-
dc.contributor.authorLillo, Concepción-
dc.contributor.authorRíos, Rosa M.-
dc.contributor.authorWittbrodt, Joachim-
dc.contributor.authorMartínez-Morales, Juan Ramón-
dc.date.accessioned2012-10-17T07:32:00Z-
dc.date.available2012-10-17T07:32:00Z-
dc.date.issued2012-10-16-
dc.identifier.citationDevelopmental Cell 23(4): 782-795 (2012)es_ES
dc.identifier.issn1534-5807-
dc.identifier.urihttp://hdl.handle.net/10261/58171-
dc.description.abstractPolarized trafficking of adhesion receptors plays a pivotal role in controlling cellular behavior during morphogenesis. Particularly, clathrin-dependent endocytosis of integrins has long been acknowledged as essential for cell migration. However, little is known about the contribution of integrin trafficking to epithelial tissue morphogenesis. Here we show how the transmembrane protein Opo, previously described for its essential role during optic cup folding, plays a fundamental role in this process. Through interaction with the PTB domain of the clathrin adaptors Numb and Numbl via an integrin-like NPxF motif, Opo antagonizes Numb/Numbl function and acts as a negative regulator of integrin endocytosis in vivo. Accordingly, numb/numbl gain-of-function experiments in teleost embryos mimic the retinal malformations observed in opo mutants. We propose that developmental regulator Opo enables polarized integrin localization by modulating Numb/Numbl, thus directing the basal constriction that shapes the vertebrate retina epithelium.es_ES
dc.description.sponsorshipThe programs “Intramural/CSIC” 200920I212, Juan de la Cierva, and FCT (Portugal) supported O.B., M.D.-M., and I.G.-R., respectively. This work was supported by grants BFU2008-04362 and BFU2011-22916.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprint-
dc.rightsopenAccesses_ES
dc.titleNumb/Numbl-Opo Antagonism Controls Retinal Epithelium Morphogenesis by Regulating Integrin Endocytosises_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.devcel.2012.09.004-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.devcel.2012.09.004es_ES
dc.identifier.e-issn1878-1551-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderFundação para a Ciência e a Tecnologia (Portugal)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001871es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
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