Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/58171
Share/Impact:
Título : Numb/Numbl-Opo Antagonism Controls Retinal Epithelium Morphogenesis by Regulating Integrin Endocytosis
Autor : Bogdanovic, Ozren, Delfino, M., Nicolás-Pérez, María, Gavilán, María P., Gago-Rodrigues, Inês, Fernández-Miñán, Ana, Lillo, Concepción, Ríos, Rosa M., Wittbrodt, Joachim, Martínez-Morales, Juan Ramón
Fecha de publicación : 16-Oct-2012
Editor: Elsevier
Citación : Developmental Cell 23(4): 782–795 (2012)
Resumen: Polarized trafficking of adhesion receptors plays a pivotal role in controlling cellular behavior during morphogenesis. Particularly, clathrin-dependent endocytosis of integrins has long been acknowledged as essential for cell migration. However, little is known about the contribution of integrin trafficking to epithelial tissue morphogenesis. Here we show how the transmembrane protein Opo, previously described for its essential role during optic cup folding, plays a fundamental role in this process. Through interaction with the PTB domain of the clathrin adaptors Numb and Numbl via an integrin-like NPxF motif, Opo antagonizes Numb/Numbl function and acts as a negative regulator of integrin endocytosis in vivo. Accordingly, numb/numbl gain-of-function experiments in teleost embryos mimic the retinal malformations observed in opo mutants. We propose that developmental regulator Opo enables polarized integrin localization by modulating Numb/Numbl, thus directing the basal constriction that shapes the vertebrate retina epithelium.
Versión del editor: http://dx.doi.org/10.1016/j.devcel.2012.09.004
URI : http://hdl.handle.net/10261/58171
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2012.09.004
Appears in Collections:(CABIMER) Artículos
(CABD) Artículos

Files in This Item:
File Description SizeFormat 
bogdanovic2012RAW.pdf1,78 MBAdobe PDFView/Open
Show full item record
 
CSIC SFX LinksSFX Query


Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.