(Institución)

Digital.CSIC > Biología y Biomedicina > Centro de Biología Molecular Severo Ochoa (CBM) > (CBM) Artículos >

Compartir

EndNote

Impacto

Registro de acceso cerrado Tau regulates the subcellular localization of calmodulin

Autor :Gómez de Barreda, Elena
Avila, Jesús
Palabras clave :Tau, Calmodulin, Calbindin
Fecha de publicación :13-may-2011
Editor:Elsevier
Citación :Biochemical and Biophysical Research Communications 408 (3): 500–504 (2011)
Resumen:Lack of tau expression in neuronal cells results in a change in the expression of few genes. However, little is known about how tau regulates gene expression. Here we show that the presence of tau could alter the subcellular localization of calmodulin, a protein that could be located at the cytoplasm or in the nucleus. Nuclear calmodulin binds to co-transcription factors, regulating the expression of genes like calbindin. In this work, we have found that in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau and that an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin.
Versión del editor:http://dx.doi.org/10.1016/j.bbrc.2011.04.082
URI :http://hdl.handle.net/10261/57922
ISSN:0006-291X
E-ISSN:1090-2104
Aparece en las colecciones: (CBM) Artículos

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.