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Closed Access item Tau regulates the subcellular localization of calmodulin

Authors:Gómez de Barreda, Elena
Avila, Jesús
Keywords:Tau, Calmodulin, Calbindin
Issue Date:13-May-2011
Citation:Biochemical and Biophysical Research Communications 408 (3): 500–504 (2011)
Abstract:Lack of tau expression in neuronal cells results in a change in the expression of few genes. However, little is known about how tau regulates gene expression. Here we show that the presence of tau could alter the subcellular localization of calmodulin, a protein that could be located at the cytoplasm or in the nucleus. Nuclear calmodulin binds to co-transcription factors, regulating the expression of genes like calbindin. In this work, we have found that in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau and that an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin.
Publisher version (URL):http://dx.doi.org/10.1016/j.bbrc.2011.04.082
E-ISSNmetadata.dc.identifier.doi = DOI:1090-2104
Appears in Collections:(CBM) Artículos

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