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Título : Tau regulates the subcellular localization of calmodulin
Autor : Gómez de Barreda, Elena, Avila, Jesús
Palabras clave : Tau
Fecha de publicación : 13-May-2011
Editor: Elsevier
Citación : Biochemical and Biophysical Research Communications 408 (3): 500–504 (2011)
Resumen: Lack of tau expression in neuronal cells results in a change in the expression of few genes. However, little is known about how tau regulates gene expression. Here we show that the presence of tau could alter the subcellular localization of calmodulin, a protein that could be located at the cytoplasm or in the nucleus. Nuclear calmodulin binds to co-transcription factors, regulating the expression of genes like calbindin. In this work, we have found that in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau and that an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin.
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ISSN: 0006-291X
Citación : Biochemical and Biophysical Research Communications 408 (3): 500–504 (2011)
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