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Breastfeeding in infancy is not associated with inflammatory status in healthy adolescents

AuthorsVérier, C.; Duhamel, A.; Béghin, Laurent; Díaz, L. E. ; Wärnberg, Julia; Marcos, Ascensión ; Gómez Martínez, Sonia ; Manios, Yannis; De Henauw, Stefaan; Sjöström, Michael; Moreno, Luis A.; Kersting, Mathilde; Breidenassel, C.; Molnar, Denes; Artero, Enrique G.; Ferrari, Marika; Widhalm, Kurt; Turck, D.; Gottrand, Frederic
Issue Date2011
PublisherAmerican Society for Nutritional Sciences
CitationJournal of Nutrition 141: 411- 417 (2011)
AbstractIt has been suggested that breast-feeding (BF) may be associated with a decreased risk of cardiovascular disease in adulthood. A low-grade inflammation is associated with an increased risk of cardiovascular disease, even in apparently healthy children. The objective of this studywas to assess the potentialmodulating effect of BF on the inflammatory status of healthy adolescents. Information on BF (duration)was obtained from parental records in 484 of 1040 healthy European urban adolescents (56.4% females) that had a blood sample obtained as part of the Healthy Lifestyle in Europe by Nutrition and Adolescence study. Blood serum inflammatory markers were measured, including high sensitivity C-reactive protein, complement factors 3 and 4, ceruloplasmin, adhesion molecules (L-selectin and soluble endothelial selectin, soluble vascular cell adhesion molecule 1, and intercellular adhesion molecule 1), cytokines, TGFβ1, and white blood cells. After univariate analysis, a propensity score, including the potential confounding factors, was computed and used to assess the association between BF and selected inflammatory markers. BF was not significantly associated with any of the selected inflammatory markers after adjustment for gender and propensity score. In our study, BF was not associated with low-grade inflammatory status in healthy adolescents, suggesting that the potential cardiovascular benefits of BF are related to other mechanisms than modulation of inflammation ormight become relevant at a later age. Groups at high risk for cardiovascular disease should be a target for further research concerning the effects of BF. © 2011 American Society for Nutrition.
Identifiersdoi: 10.3945/jn.110.128249
issn: 0022-3166
Appears in Collections:(ICTAN) Artículos
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