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Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes

AuthorsKumar, Rashmi ; Férez, María ; Swamy, Mahima; Arechaga, Ignacio ; Rejas, M. Teresa ; Valpuesta, José M. ; Schamel, Wolfgang; Alarcón, Balbino ; Santen, Hisse M. van
KeywordsT cells
CD3 subunit
Issue Date23-Sep-2011
CitationImmunity 35:375-387 (2011)
AbstractAlthough memory T cells respond more vigorously to stimulation and they are more sensitive to low doses of antigen than naive T cells, the molecular basis of this increased sensitivity remains unclear. We have previously shown that the T cell receptor (TCR) exists as different-sized oligomers on the surface of resting T cells and that large oligomers are preferentially activated in response to low antigen doses. Through biochemistry and electron microscopy, we now showed that previously stimulated and memory T cells have more and larger TCR oligomers at the cell surface than their naive counterparts. Reconstitution of cells and mice with a point mutant of the CD3ζ subunit, which impairs TCR oligomer formation, demonstrated that the increased size of TCR oligomers was directly responsible for the increased sensitivity of antigen-experienced T cells. Thus, we propose that an “avidity maturation” mechanism underlies T cell antigenic memory.
DescriptionIncluye abstract gráfico
Publisher version (URL)http://dx.doi.org/10.1016/j.immuni.2011.08.010
Appears in Collections:(CBM) Artículos
(CNB) Artículos
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