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Registro de acceso cerrado T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis

Autor :Martínez Martín, Nuria
Fernández-Arenas, Elena
Delgado, Pilar
Bustelo, Xosé R.
Alarcón, Balbino
Palabras clave :Immunological synapse, T cell receptor
Fecha de publicación :26-ago-2011
Citación :Immunity 35(2): 208–222 (2011)
Resumen:The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated in tonic TCR signaling by activating phosphatidylinositol 3-kinase. In this study, we demonstrate that TC21 both cotranslocates with the TCR to the IS and is necessary for TCR internalization from the IS through a mechanism dependent on RhoG, a small GTPase previously associated with phagocytosis. Indeed, we found that the TCR triggers T cells to phagocytose 1–6 μm beads through a TC21- and RhoG-dependent pathway. We further show that TC21 and RhoG are necessary for the TCR-promoted uptake of major histocompatibility complex (MHC) from antigen-presenting cells. Therefore, TC21 and RhoG dependence underlie the existence of a common phagocytic mechanism that drives TCR internalization from the IS together with its peptide-MHC ligand.
Versión del editor:http://dx.doi.org/10.1016/j.immuni.2011.06.003
URI :http://hdl.handle.net/10261/57533
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