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Registro de acceso cerrado Presynaptic GABA A receptors enhance transmission and LTP induction at hippocampal mossy fiber synapses

Autor :Ruiz, Arnaud
Campanac, Emilie
Scott, Ricardo S.
Rusakov, Dmitri A.
Kullmann, Dimitri M.
Fecha de publicación :2010
Editor:Nature Publishing Group
Citación :Nature Neuroscience 13(4): 431- 438 (2010)
Resumen:Presynaptic GABA A receptors (GABA A Rs) occur at hippocampal mossy fiber synapses. Whether and how they modulate orthodromic signaling to postsynaptic targets is poorly understood. We found that an endogenous neurosteroid that is selective for high-affinity subunit-containing GABA A Rs depolarized rat mossy fiber boutons, enhanced action potential-dependent Ca 2+ transients and facilitated glutamatergic transmission to pyramidal neurons. Conversely, blocking GABA A Rs hyperpolarized mossy fiber boutons, increased their input resistance, decreased spike width and attenuated action potential-dependent presynaptic Ca 2+ transients, indicating that a subset of presynaptic GABA receptors are tonically active. Blocking GABA A Rs also interfered with the induction of long-term potentiation at mossy fiber-CA3 synapses. Presynaptic GABA A Rs therefore facilitate information flow to the hippocampus both directly and by enhancing LTP. © 2010 Nature America, Inc. All rights reserved.
URI :http://hdl.handle.net/10261/57333
Identificadores:doi: 10.1038/nn.2512
issn: 1097-6256
e-issn: 1546-1726
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