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Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea

AuthorsParra, Andrés; Madrid, Rodolfo; Echevarría, Diego; Olmo, Susana del; Morenilla-Palao, Cruz; Acosta, M. Carmen; Gallar, Juana; Dhaka, Ajay; Viana, Félix; Belmonte, Carlos
Issue Date2010
PublisherNature Publishing Group
CitationNature Medicine 16(12): 1396- 1399 (2010)
AbstractBasal tearing is crucial to maintaining ocular surface wetness. Corneal cold thermoreceptors sense small oscillations in ambient temperature and change their discharge accordingly. Deletion of the cold-transducing ion channel Transient receptor potential cation channel subfamily M member 8 (TRPM8) in mice abrogates cold responsiveness and reduces basal tearing without affecting nociceptor-mediated irritative tearing. Warming of the cornea in humans also decreases tearing rate. These findings indicate that TRPM8-dependent impulse activity in corneal cold receptors contributes to regulating basal tear flow. © 2010 Nature America, Inc. All rights reserved.
Identifiersdoi: 10.1038/nm.2264
issn: 1078-8956
e-issn: 1546-170X
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