Please use this identifier to cite or link to this item:
Título : In vitro biocompatibility evaluation of surface-modified titanium alloys
Autor : Treves, C., Martinesi, M., Stio, M., Gutiérrez, A., Jiménez, José Antonio, López, M. F.
Palabras clave : Titanium alloy
Surface treatment
Endothelial cells
Blood mononuclear cells
Fecha de publicación : 2010
Editor: John Wiley & Sons
Citación : Journal of Biomedical Materials Research Part A 92(4) : 1623-1634 (2010)
Resumen: The present work is aimed to evaluate the effects of a surface modification process on the biocompatibility of three vanadium-free titanium alloys with biomedical applications interest. Chemical composition of alloys investigated, in weight %, were Ti-7Nb-6Al, Ti-13Nb-13Zr, and Ti-15Zr-4Nb. An easy and economic method intended to improve the biocompatibiblity of these materials consists in a simple thermal treatment at high temperature, 750°C, in air for different times. The significance of modification of the surface properties to the biological response was studied putting in contact both untreated and thermally treated alloys with human cells in culture, Human Umbilical Vein Endothelial Cells (HUVEC) and Human Peripheral Blood Mononuclear Cells (PBMC). The TNF-α release data indicate that thermal treatment improves the biological response of the alloys. The notable enhancement of the surface roughness upon oxidation could be related with the observed reduction of the TNF-α levels for treated alloys. A different behavior of the two cell lines may be observed, when adhesion molecules (ICAM-1 and VCAM-1 in HUVEC, ICAM-1, and LFA-1 in PBMC) were determined, PBMC being more sensitive than HUVEC to the contact with the samples. The data also distinguish surface composition and corrosion resistance as significant parameters for the biological response.
Versión del editor:
DOI: 10.1002/jbm.a.32507
Appears in Collections:(CENIM) Artículos

Files in This Item:
There are no files associated with this item.
Show full item record

Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.