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Title: Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus - the producing organism
Authors: Pardo, José M., Malpartida Romero, Francisco, Rico, Manuel, Jiménez Díaz, Antonio
Issue Date: 1985
Publisher: Society for General Microbiology
Abstract: Hygromycin B, an aminocyclitol antibiotic that strongly inhibits both 70sand 80s ribosomes, is synthesized by Streptomyces hygroscopicus. Ribosomes from this Gram-positive mycelial bacterium are inhibited in vitro by the antibiotic. In contrast, the streptomycete is highly resistant to the drug in vivo since it possesses hygromycin B phosphotransferase activity. This enzyme has been shown by gel filtration to have a molecular weight of 42000,and to modify its antibiotic substrate to produce 7>-O-phosphoryl-hygromycinB which totally lacks biological activity both in vivo and in vitro.
Identifiers: doi: 10.1099/00221287-131-6-1289
issn: 0022-1287
Citation: Journal of General Microbiology 131: 1289- 1298 (1985)
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