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Título: | Probiotic strains: survival under simulated gastrointestinal conditions, in vitro adhesion to caco-2 cells and effect on cytokine secretion |
Autor: | Fernández de Palencia, P. CSIC; López García, Paloma CSIC ORCID ; Corbí, Angel L. ; Peláez-Martínez, María Carmen; Requena, Teresa CSIC ORCID | Palabras clave: | Probiotic bacteria Lactic acid bacteria Gastrointestinal stress Adhesion Immunomodulation |
Fecha de publicación: | 2008 | Editor: | Springer Nature | Citación: | European Food Research and Technology 227(5):1475–1484(2008) | Resumen: | This study evaluated three probiotic strains (Lactobacillus paracasei subsp. paracasei LC-01, L. acidophilus LA-5, Bifidobacterium lactis Bb-12) and two yoghurt strains (L. delbrueckii subsp. bulgaricus LBY-27 and Streptococcus thermophilus STY-31) with regard to their resistance to simulated gastrointestinal stress, and their ability to interact with human intestinal epithelial cells. The viability of strains was analyzed by measurements of fluorescence-stained cells and their growth by plate colony-counts. The results reveal that for all tested strains, gastric emptying (above pH 3.0) would release a large number of viable cells ranging from 91% for L. paracasei to 53% for S. thermophilus into the intestinal tract, and that between 12 and 23% of them subsequently survive intestinal stress. Among them L. paracasei showed the highest resistance to gastric stress. All the bacteria adhered to the Caco-2 cell line, with the highest adhesions being observed for L. delbrueckii subsp. bulgaricus (9%) and L. acidophilus (7%). Binding of all strains to Caco-2 cells did not result in a significant increase in the production of IL-6 and IL-8 cytokines, suggesting that these bacteria do not trigger an overt inflammatory response in human intestine epithelial cells | Descripción: | 31 p.-4 fig.-2 tab.-1 supl. tab.-1 supl. fig. | Versión del editor: | http://dx.doi.org/10.1007/s00217-008-0870-6 | URI: | http://hdl.handle.net/10261/57184 | DOI: | 10.1007/s00217-008-0870-6 | ISSN: | 1438-2377 | E-ISSN: | 1438-2385 |
Aparece en las colecciones: | (CIB) Artículos (IF) Artículos |
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European Food Research and Technology -Fdez. de Palenciapdf.pdf | 462,72 kB | Adobe PDF | Visualizar/Abrir |
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