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Arabidopsis Synaptotagmin 1 is required for the maintenance of plasma membrane integrity and cell viability

AuthorsLópez-Cobollo, Rosa María; Salinas, Julio ; Valpuesta, Victoriano; Botella, Miguel A.
Issue DateDec-2008
PublisherAmerican Society of Plant Biologists
CitationPlant Cell 20(12):3374-3388(2008)
AbstractPlasma membrane repair in animal cells uses synaptotagmin 7, a Ca2+-activated membrane fusion protein that mediates delivery of intracellular membranes to wound sites by a mechanism resembling neuronal Ca2+-regulated exocytosis. Here, we show that loss of function of the homologous Arabidopsis thaliana Synaptotagmin 1 protein (SYT1) reduces the viability of cells as a consequence of a decrease in the integrity of the plasma membrane. This reduced integrity is enhanced in the syt1-2 null mutant in conditions of osmotic stress likely caused by a defective plasma membrane repair. Consistent with a role in plasma membrane repair, SYT1 is ubiquitously expressed, is located at the plasma membrane, and shares all domains characteristic of animal synaptotagmins (i.e., an N terminus-transmembrane domain and a cytoplasmic region containing two C2 domains with phospholipid binding activities). Our analyses support that membrane trafficking mediated by SYT1 is important for plasma membrane integrity and plant fitness
Description15 páginas, 6 figuras.-- et al.
Publisher version (URL)http://dx.doi.org/10.1105/tpc.108.063859
Appears in Collections:(CIB) Artículos
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