English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/5700
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Adult olfactory bulbs from primates provide reliable ensheathing glia for cell therapy

AuthorsRubio Rodríguez, María Paz; Muñoz-Quiles, Cintia ; Ramón-Cueto, Almudena
Keywordslifespan
monkey
neural regeneration
senescence
long-term culture
p75
Issue Date31-Jan-2008
PublisherWiley-Liss
CitationGlia 56 (5): 539-551 (2008)
AbstractOlfactory bulb ensheathing glia (OB-OEG) from adult rodents promote functional and morphological repair after grafting into injured spinal cords. To provide insight into the feasibility of using OB-OEG in human therapy, we studied OB-OEG in primates to determine their suitability for spinal cord transplantation. Here we show that OEG can be obtained from olfactory bulbs of adult macaca mulatta and nemestrina monkeys and compare their characteristics to those obtained from rats. In contrast to rodent OBOEG, primate OB-OEG are non-senescent, exhibit a longer lifespan, are less sensitive to high oxygen culture environment, and maintain a phenotype suitable for grafting for up to 2.5 months in vitro. Three-week cultures (short term) derived from a single macaca olfactory bulb provide enough OEG for autologous transplantation at the acute stage of injury, and after long-term cultures (2.5 months) may yield an additional 20 billion. OEG can be frozen for later use. Therefore, primate adult olfactory bulbs constitute a reliable source of OEG for cell therapy, and successful culture of these cells make autologous transplantation feasible.
DescriptionThe definitive version is available at http://www3.interscience.wiley.com/cgi-bin/fulltext/117905156/PDFSTART
Publisher version (URL)http://dx.doi.org/10.1002/glia.20635
URIhttp://hdl.handle.net/10261/5700
DOI10.1002/glia.20635
Appears in Collections:(IBV) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.