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Binding of complement regulatory proteins to Group A Streptococcus

AutorOliver, María Antonia; Rojo, José María ; Rodríguez de Córdoba, Santiago ; Albertí, Sebastián
Palabras claveStreptococcus pyogenes
Factor H
Factor H-like protein 1
C4b-binding protein
CD46
Fecha de publicacióndic-2008
EditorElsevier
CitaciónVaccine 26(8S):175-178(2008)
ResumenStreptococcus pyogenes or Group A Streptococcus (GAS) is the etiologic agent of important human infections such as acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Binding of the complement regulatory proteins factor H, factor H-like protein 1 (FHL-1), C4b-binding protein (C4BP), or CD46 is a crucial step in the pathogenesis of these infections. M protein is the GAS protein that generally mediates these interactions. However, a detailed analysis of the reports that have investigated the binding of complement regulatory components to GAS indicates that this microorganism has evolved alternative mechanisms for the recruitment of complement regulatory proteins to the bacterial surface. This article summarizes these data to provide a starting point for future research aimed at the characterization of additional mechanisms developed by GAS to evade the immune system
Descripción4 páginas, 1 figura -- PAGS nros. 175-178
Versión del editorhttp://dx.doi.org/10.1016/j.vaccine.2008.11.054
URIhttp://hdl.handle.net/10261/56527
DOI10.1016/j.vaccine.2008.11.054,
ISSN0264-410X
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