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Closed Access item Preparation of Targeting Vehicles for the Delivery of NBisphosphonates

Authors:Rodríguez-Lorenzo, L. M.
Fernández, M.
Parra, J.
Vázquez-Lasa, Blanca
López-Bravo, A.
San Román, Julio
Gross, K. A.
Anderson, Gail I.
Keywords:N-bisphosphonates, hydroxyfluorapatites, drug delivery systems
Issue Date:2007
Publisher:Trans Tech Publications
Citation:Key Engineering Materials 330-332 : 1041-1044 (2007)
Abstract:Bisphosphonates (BP) are drugs currently administered orally to treat diseases characterised by an excessive bone resorption. Alternative and more efficient delivery routes and more potent compounds are being investigated. Three implantable delivery systems, which allow the controlled release of therapeutic agents from the device core, are examined in this paper. (4- (aminomethyl) benzene) bisphosphonic acid (ABBP) was incorporated on Ca8.8Na0.8(PO4)4.8(CO3)1.2(OH)0.4F1.6 particles by refluxing the powder in a 60 mmol suspension in acetone at 60ºC for 5 hours. 4-aminophenyl acetic bisphosphonate monosodium salt (APBP) and 1- H-indole-3-acetic bisphosphonate monosodium (IBP) were loaded on Ca10(PO4)6(OH)1F1 ceramic bodies by stirring the ceramic bodies in 0.04M BP solutions. Injectable acrylic cements based on self-curing formulations of methyl methacrylate (MMA) and vitamin E were loaded with APBP and IBP. The incorporation of ABBP was confirmed by MAS-NMR spectroscopy. Modified powder shows two different phosphorous environments, the first one at 2.91 ppm can be assigned to the apatite base and the second one at 18.0 ppm has to be attributed to the phosphonic group of the ABBP. The IBP addition on ceramic surfaces did not decrease the number of osteoclast colonies and appeared to improve the performance of the HA as a surface for osteoblast culture. A therapeutic dosage of APBP and IBP can be achieved from acrylic cements that showed lack of toxicity and an increased cellular activity and proliferation
Publisher version (URL):http://dx.doi.org/10.4028/www.scientific.net/KEM.330-332.1041
URI:http://hdl.handle.net/10261/56459
ISSN:1013-9826
Appears in Collections:(ICTP) Artículos

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