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Title

Synthesis of BODIPY-labeled alkylphosphocholines with leishmanicidal activity, as fluorescent analogues of miltefosine

AuthorsHornillos, Valentín ; Carrillo, Eugenia ; Rivas, Luis ; Amat-Guerri, Francisco ; Acuña, A. Ulises
KeywordsMiltefosine
Hexadecylphosphocholine
Leishmaniasis;
Parasiticide
BODIPY
Fluorescent lipids
Issue Date15-Dec-2008
PublisherElsevier
CitationBioorganic and Medicinal Chemistry Letters 18(24):6336-63399(2008)
AbstractTwo general synthetic methods are described, by which the highly fluorescent and photostable BODIPY group can be inserted in and aligned with the alkyl backbone of linear lipids. These methods have been used to prepare strongly emitting analogues of the leishmanicidal drug miltefosine, in which the antiparasite activity in vitro of the original drug is preserved
Description4 páginas, 2 figuras, 2 tablas, 2 esquemas -- PAGS nros. 6336-6339
Publisher version (URL)http://dx.doi.org/10.1016/j.bmcl.2008.10.089
URIhttp://hdl.handle.net/10261/56371
DOI10.1016/j.bmcl.2008.10.089
ISSN0960-894X
Appears in Collections:(CIB) Artículos
(IQFR) Artículos
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