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Título: | Th17 and treg cells, two new lymphocyte subpopulations with a key role in the immune response against infection |
Autor: | Vernal, Rolando; García-Sanz, José A. CSIC ORCID | Palabras clave: | T lymphocytes T cells T cell subsets helper T cells Th17 RORC2 RORγt regulatory T cells Treg cells Foxp3 |
Fecha de publicación: | abr-2008 | Editor: | Bentham Science Publishers | Citación: | Infectious Disorders - Drug Targets 8(4):207-220 (2009) | Resumen: | In addition to the T helper 1 (Th1) and Th2 lymphocyte subsets, two new subpopulations Th17 and regulatory T (Treg) cells have recently been described. Th17 cells, which produce high levels of interleukin (IL)-17, are dependent on the transcription factor orphan nuclear receptor RORC2/RORgammat and have been implicated in exacerbating the immune response to infections. Conversely, Treg cells, either thymus-derived or generated upon TCR activation of naîve T cells, express the transcription factor forkhead box P3 (Foxp3) and have regulatory functions mediated through either direct cell-cell contact or immuno-suppressive cytokines, being able to suppress the activation of T, B and NK cells. Based on the current knowledge of Th17 and Treg cell functions, new therapeutic strategies start to emerge, involving anti-cytokine treatments targeting Th17 functions or cell-based treatments in which Treg cells are generated from T cells either through Foxp3 gene transfer onto T cells with known specificities or transferring specific TCR genes onto Treg cells | Descripción: | 14 páginas, 4 figuras, 1 tabla -- PAGS nros. 207-220 | Versión del editor: | http:// dx.doi.org/10.2174/187152608786734197 | URI: | http://hdl.handle.net/10261/56112 | DOI: | 10.2174/187152608786734197 | ISSN: | 1871-5265 | E-ISSN: | 2212-3989 |
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