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Título

Th17 and treg cells, two new lymphocyte subpopulations with a key role in the immune response against infection

AutorVernal, Rolando; García-Sanz, José A. CSIC ORCID
Palabras claveT lymphocytes
T cells
T cell subsets
helper T cells
Th17
RORC2
RORγt
regulatory T cells
Treg cells
Foxp3
Fecha de publicaciónabr-2008
EditorBentham Science Publishers
CitaciónInfectious Disorders - Drug Targets 8(4):207-220 (2009)
ResumenIn addition to the T helper 1 (Th1) and Th2 lymphocyte subsets, two new subpopulations Th17 and regulatory T (Treg) cells have recently been described. Th17 cells, which produce high levels of interleukin (IL)-17, are dependent on the transcription factor orphan nuclear receptor RORC2/RORgammat and have been implicated in exacerbating the immune response to infections. Conversely, Treg cells, either thymus-derived or generated upon TCR activation of naîve T cells, express the transcription factor forkhead box P3 (Foxp3) and have regulatory functions mediated through either direct cell-cell contact or immuno-suppressive cytokines, being able to suppress the activation of T, B and NK cells. Based on the current knowledge of Th17 and Treg cell functions, new therapeutic strategies start to emerge, involving anti-cytokine treatments targeting Th17 functions or cell-based treatments in which Treg cells are generated from T cells either through Foxp3 gene transfer onto T cells with known specificities or transferring specific TCR genes onto Treg cells
Descripción14 páginas, 4 figuras, 1 tabla -- PAGS nros. 207-220
Versión del editorhttp:// dx.doi.org/10.2174/187152608786734197
URIhttp://hdl.handle.net/10261/56112
DOI10.2174/187152608786734197
ISSN1871-5265
E-ISSN2212-3989
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