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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/56055
Title: Thiourea catalyzed organocatalytic enantioselective Michael addition of diphenyl phosphite to nitroalkenes
Authors: Alcaine, Ana; Marqués-López, Eugenia; Merino, Pedro; Tejero, Tomás; Herrera, Raquel P.
Issue Date: 2011
Publisher: Royal Society of Chemistry (Great Britain)
Citation: Organic and Biomolecular Chemistry 9(8): 2777-2783 (2011)
Abstract: Bifunctional thiourea catalyzes the enantioselective Michael addition reaction of diphenyl phosphite to nitroalkenes. This methodology provides a facile access to enantiomerically enriched β-nitrophosphonates, precursors for the preparation of synthetically and biologically useful β-aminophosphonic acids. DFT level of computational calculations invoke the attack of the diphenyl phosphite to the nitroolefin by the Re face, this give light to this scarcely explored process update in the literature. The computational calculations support the absolute configuration obtained in the final adducts.
Description: 7 páginas, 5 figuras, 4 tablas, 1 esquema.
Publisher version (URL): http://dx.doi.org/10.1039/C0OB01059F
URI: http://hdl.handle.net/10261/56055
ISSN: 1477-0520
DOI: 10.1039/C0OB01059F
E-ISSN: 1477-0539
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