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Title: Thiolato gold(I) complexes containing water-soluble phosphane ligands: a characterization of their chemical and biological properties
Authors: Vergara, Elena, Cerrada, Elena, Laguna, Mariano
Issue Date: 2011
Publisher: Royal Society of Chemistry (Great Britain)
Abstract: A series of thiolate gold(I) derivatives bearing water soluble phosphanes – namely sodium triphenylphosphane monosulfonate (TPPMS), sodium triphenylphosphane trisulfonate (TPPTS), 1,3,5-triaza-7-phosphaadamantane (PTA) and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) – is reported and the compounds studied for their luminescence properties in the solid state. Two of these derivatives, [Au(SMe2pyrim)(PTA)] and [Au(SBenzoxazole)(DAPTA)], are also structurally characterized by X-ray diffraction analysis. Strong antiproliferative effects are observed for most of the compounds in the human ovarian carcinoma cell lines (A2780/S) and its cisplatin-resistant variant (A2780/R), which depend on both the type of thiolate and phosphane ligands. ICP-MS studies were also performed to evaluate the influence of the gold uptake on the cytotoxic potency of the compounds.
Description: 9 páginas, 3 figuras, 5 tablas, 1 esquema.-- et al.
Publisher version (URL): http://dx.doi.org/10.1039/C1DT10892A
URI: http://hdl.handle.net/10261/56052
ISSN: 1477-9226
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Citation: Dalton Transactions 40(41): 10927-10935 (2011)
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