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dc.contributor.authorPacheco, Yolanda M.-
dc.contributor.authorAbia, Rocío-
dc.contributor.authorPerona, Javier S.-
dc.contributor.authorReina, Manuel-
dc.contributor.authorRuiz-Gutiérrez, Valentina-
dc.contributor.authorMontero, Emilio-
dc.contributor.authorMuriana, Francisco J. G.-
dc.identifier.citationJournal of Agricultural and Food Chemistry 49(11): 5653-5661 (2001)es_ES
dc.identifier.otherPMID: 11714373-
dc.description.abstractPlasma triacylglycerol-rich lipoproteins (TRL) are being considered as a key lipid fraction in the pathogenesis of atherosclerotic cardiovascular disease. Here we compared the influence of two monounsaturated oils [virgin olive oil (VOO) and high-oleic sunflower oil (HOSO)] on the capability of postprandial TRL to interact with two human vascular cell lines [umbilical vein endothelial (HUVEC) and aorta smooth muscle (HASMC) cells]. A fluorescent probe was used for labeling TRL and to determine receptor activity of HUVEC and HASMC. The values for total cell-associated, bound, and internalized TRL were higher in HUVEC, and TRL from VOO was the better ligand recognized but at lower affinity than TRL from HOSO. There was a competitive effect of very low density lipoproteins (VLDL) for the uptake of TRL by cells, which was found to be dependent on the origin/lipid composition of the ligands and cell-type specific. We also conclude that the VLDL receptor (VLDLr) may contribute significantly to the HASMC binding capacity for postprandial TRL mediated by lipoprotein lipase (LPL) or LPL-binding molecules. Our findings are compatible with a selective role of the clustered O-linked sugar domain of the VLDLr in the catabolism of TRL by human vascular cells.es_ES
dc.publisherAmerican Chemical Societyes_ES
dc.subjectTriacylglycerol-rich lipoproteinses_ES
dc.subjectHuman vascular cellses_ES
dc.subjectMembrane receptorses_ES
dc.subjectDietary monounsaturated oilses_ES
dc.titleTriacylglycerol-Rich Lipoproteins Interact with Human Vascular Cells in a Lipid-Dependent Fashiones_ES
dc.description.peerreviewedPeer reviewedes_ES
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