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http://hdl.handle.net/10261/55920
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Pacheco, Yolanda M. | - |
dc.contributor.author | Abia, Rocío | - |
dc.contributor.author | Perona, Javier S. | - |
dc.contributor.author | Reina, Manuel | - |
dc.contributor.author | Ruiz-Gutiérrez, Valentina | - |
dc.contributor.author | Montero Romero, Emilio | - |
dc.contributor.author | Muriana, Francisco J. G. | - |
dc.date.accessioned | 2012-09-10T09:28:32Z | - |
dc.date.available | 2012-09-10T09:28:32Z | - |
dc.date.issued | 2001-11 | - |
dc.identifier.citation | Journal of Agricultural and Food Chemistry 49(11): 5653-5661 (2001) | es_ES |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.other | PMID: 11714373 | - |
dc.identifier.uri | http://hdl.handle.net/10261/55920 | - |
dc.description.abstract | Plasma triacylglycerol-rich lipoproteins (TRL) are being considered as a key lipid fraction in the pathogenesis of atherosclerotic cardiovascular disease. Here we compared the influence of two monounsaturated oils [virgin olive oil (VOO) and high-oleic sunflower oil (HOSO)] on the capability of postprandial TRL to interact with two human vascular cell lines [umbilical vein endothelial (HUVEC) and aorta smooth muscle (HASMC) cells]. A fluorescent probe was used for labeling TRL and to determine receptor activity of HUVEC and HASMC. The values for total cell-associated, bound, and internalized TRL were higher in HUVEC, and TRL from VOO was the better ligand recognized but at lower affinity than TRL from HOSO. There was a competitive effect of very low density lipoproteins (VLDL) for the uptake of TRL by cells, which was found to be dependent on the origin/lipid composition of the ligands and cell-type specific. We also conclude that the VLDL receptor (VLDLr) may contribute significantly to the HASMC binding capacity for postprandial TRL mediated by lipoprotein lipase (LPL) or LPL-binding molecules. Our findings are compatible with a selective role of the clustered O-linked sugar domain of the VLDLr in the catabolism of TRL by human vascular cells. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Triacylglycerol-rich lipoproteins | es_ES |
dc.subject | Human vascular cells | es_ES |
dc.subject | Membrane receptors | es_ES |
dc.subject | Dietary monounsaturated oils | es_ES |
dc.title | Triacylglycerol-Rich Lipoproteins Interact with Human Vascular Cells in a Lipid-Dependent Fashion | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1021/jf010576n | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1021/jf010576n | es_ES |
dc.identifier.e-issn | 1520-5118 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
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